Hair growth‐promotion effects of different alternating current parameter settings are mediated by the activation of Wnt/β‐catenin and MAPK pathway
|City lights viewed in a motion blurred exposure. The AC blinking causes the lines to be dotted rather than continuous. (Photo credit: Wikipedia)|
Electrical stimulation is being used in variable skin therapeutic conditions. There have been clinical studies demonstrating the positive effect of electrical stimuli on hair regrowth. However, the underlying exact mechanism and optimal parameter settings are not clarified yet. To investigate the effects of different parameter settings of electrical stimuli on hair growth by examining changes in human dermal papilla cells (hDPCs) in vitro and by observing molecular changes in animal tissue. In vitro, cultured hDPCs were electrically stimulated with different parameter settings at alternating current (AC). Cell proliferation was measured by MTT assay. The Ki67 expression was measured by immunofluorescence. Hair growth‐related gene expressions were measured by RT‐PCR.